April 11, 2014
by Helayne

New study: Reishi mushrooms inhibit metastases

Int J Oncol. 2014 Apr 9. doi: 10.3892/ijo.2014.2375. [Epub ahead of print]

The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes.

Loganathan J1, Jiang J1, Smith A1, Jedinak A1, Thyagarajan-Sahu A1, Sandusky GE2, Nakshatri H3, Sliva D1.

Author information

  • 1Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA.
  • 2Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • 3Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.


Breast cancer metastasis is one of the major reasons for the high morbidity and mortality of breast cancer patients. In spite of surgical interventions, chemotherapy, radiation therapy and targeted therapy, some patients are considering alternative therapies with herbal/natural products. In the present study, we evaluated a well-characterized extract from the medicinal mushroom Ganoderma lucidum (GLE) for its affects on tumor growth and breast-to-lung cancer metastasis. MDA-MB-231 human breast cancer cells were implanted into the mammary fat pads of nude mice. GLE (100 mg/kg/every other day) was administered to the mice by an oral gavage for 4 weeks, and tumor size was measured using microcalipers. Lung metastases were evaluated by hematoxylin and eosin (H&E) staining. Gene expression in MDA-MB-231 cells was determined by DNA microarray analysis and confirmed by quantitative PCR. Identified genes were silenced by siRNA, and cell migration was determined in Boyden chambers and by wound-healing assay. Although an oral administration of GLE only slightly suppressed the growth of large tumors, the same treatment significantly inhibited the number of breast-to-lung cancer metastases. GLE also downregulated the expression of genes associated with invasive behavior (HRAS, VIL2, S100A4, MCAM, I2PP2A and FN1) in MDA-MB-231 cells. Gene silencing of HRAS, VIL2, S100A4, I2PP2A and FN1 by siRNA suppressed migration of MDA-MB‑231 cells. Our study suggests that an oral administration of GLE can inhibit breast-to-lung cancer metastases through the downregulation of genes responsible for cell invasiveness. The anti-metastatic benefits of GLE warrant further clinical studies.

February 24, 2014
by Helayne

First Annual Cure to Cancer Conference coming to San Diego in April

  1. I highly encourage you to join me for the Cure to Cancer Conference in San Diego April 25th-27th for a weekend of inspiration, education, networking, support, and empowering keynote presentations highlighting leading edge research around preventing, healing, and reversing cancer.

    This empowering conference is happening in a beautiful bay-side San Diego location with a free shuttle from the airport. I am thrilled to be speaking alongside over a dozen expert presenters: scientists, doctors, nutritionists, researchers, and cancer survivors and thrivers who will share with you their latest information around preventing, healing, and reversing cancer.

    See What it’s All About:

    The weekend event will kick off with a Friday night gala dinner and keynote presentations, networking, intimate time with the presenters, and entertainment to jump start the momentum.

    This is an opportunity to sit face to face with the leaders in the industry and ask them your most pressing questions.

    You will learn new scientific breakthroughs, hear from cancer survivors how they beat cancer, and be inspired by these leaders during a 3 day weekend gathering of gentle and passionate souls.

    I highly encourage you join me, other practitioners, researchers, and world leading experts during this life changing weekend event.

    Get Your Tickets Today: http://thecuretocancersummit.com/dap/a/?a=1821

    Very best,

    Helayne Waldman

February 6, 2014
by Helayne

Pomegranate Power!

Inflammation. 2014 Jan 29. [Epub ahead of print]

Punicalagin Inhibits Inflammation in LPS-Induced RAW264.7 Macrophages via the Suppression of TLR4-Mediated MAPKs and NF-κB Activation.

Xu X, Yin P, Wan C, Chong X, Liu M, Cheng P, Chen J, Liu F, Xu J.



Punicalagin (2,3,hexahydroxydiphenoyl-gallagyl-D-glucose and referred to as PUN) is a bioactive ellagitannin isolated from pomegranate, which is widely used for the treatment of inflammatory bowel disease (IBD), diarrhea, and ulcers in Chinese traditional medicine. In this study, we detected the anti-inflammation potentials of PUN in lipopolysaccharide (LPS)-induced macrophages and tried to uncover the underlying mechanism. Results demonstrated that PUN (25, 50, or 100 μM) treatment could significantly decrease the LPS-induced production of nitric oxide), prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in RAW264.7 cells. Molecular research showed that PUN inhibited the activation of upstream mediator nuclear factor-κB by suppressing the phosphorylation of IκBα and p65. Results also indicated that PUN could suppress the phosphorylation of mitogen-activated protein kinase including p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase. In conclusion, we observed that PUN could inhibit LPS-induced inflammation, and it may be a potential choice for the treatment of inflammation diseases.


February 5, 2014
by Helayne

Chocolate is for lovers and octogenarians

by Helayne Waldman

Chocolate is for Lovers and Octogenarians


It’s almost Valentine’s Day, and millions of American women are looking forward to the smoothest textured, the most seductively sweet and unashamedly romantic gift of all: a box of heart-stopping chocolates.

But lest you think that chocolate is one of those phenomena that’s quintessentially American, consider the fact that the Aztec and Mayans cultivated “theobroma cacao” for centuries before the arrival of the Europeans. Theobroma cacao” translates literally as “food of the gods.” In fact, the Mayans used this heavenly treat as currency (according to a 16th Century Spanish source, a Mayan mule once cost 60 cacao beans), and when the Europeans brought it home, it quickly became the favorite of the royal courts of Europe. Civilizations from Brazil to Belarus have hailed chocolate as an aphrodisiac, and the U.S. government officially lauded it in World War II by making it standard issue for the military. Today, more and more studies are validating that our cocoa- consuming predecessors were certainly on to something big.

To start, we women have always been sweet on the stuff because it elevates mood and associates us with feelings of love and comfort. But there’s much more to the story for both women and men alike.

Review, for example, chocolate’s impressive cast of flavonoids. Flavonoids are chemical compounds with antioxidant properties that plants use to protect themselves from environmental toxins. When we eat the plants that contain these chemicals, we too reap the benefits.

Scientists have recently discovered a particular type of powerful flavanoid in chocolate, called epicatechin. In chocolate, primarily the dark variety, flavanoids are plentiful, and provide a powerful cardiovascular boost. In addition to quenching free radicals, those destructive metabolic byproducts that can wreak havoc on our blood vessels along with every other organ, the specific flavanoids in chocolate, like those in red wine, have also been found to:

  • Decrease “bad” LDL cholesterol
  • Raise “good” HDL cholesterol
  • Reduce the tendency of the blood to form dangerous clots
  • Relax the blood vessels which inhibit an enzyme that causes inflammation, a major cause of heart disease

If you’re worried about the high fat content of the chocolate, your concerns are both valid and unfounded. True, the bar, with a 50 percent fat content is high in calories, and like anything sweet and fatty, should clearly be eaten in moderation. The cocoa butter fat in chocolate, however, is by and large of the “good guy” variety. Oleic acid, for example, is the healthy monounsaturated fat for which olive oil is feted.. And the evidence is stacking up that the stearic acid in cocoa butter, although a saturated fat, is in fact responsible for raising those protective HDLs.

Got a cough this Valentine’s Day? Don’t worry, a recent study found that theobromine, a derivative in cocoa, was nearly a third more effective than codeine in suppressing the common cough, due to its inhibition of the cranial nerve responsible for coughing.

And if that weren’t enough, it even appears that dark chocolate has an impact on longevity, when eaten regularly in moderation. Indeed, no less august an institution than Harvard postulated, in a public health study, that chocolate- eating added nearly a year to men’s lives, after accounting for weight, smoking status and other factors.

Not bad for a candy bar, eh? Remember, however, it’s only the dark chocolate that has been shown to have this powerful effect. So make sure it’s of exceptional quality, with at least 70 percent cocoa content, and if at all possible, organic. After all, you want only the best when it comes to guarding your health AND romancing your sweetheart.

February 5, 2014
by Helayne

We’ll be participating in Annie Appleseed Conference and so should You!

Annie Appleseed Project presents its 8th Evidence-based CAM for Cancer conference featuring exciting speakers, organic buffet lunches, clean water, access to all exhibitors, a giveaway (reusable bag) with items of value and interest, a Prize drawing, great networking, and Florida weather.

Cost is $249 (all inclusive). Hotel Link is up.  Rooms are $169 for King or 2 Queen Suite until January 16, then $179 through February 20 or until block is sold out.  Register EARLY.

Friday KEYNOTE: Keith Block, MD, Chief Medical Office, Block Medical Center

FREE Movie on Friday night: Numen the Language of Plants

Saturday KEYNOTE: Michael Schachter, MD, Schachter Center for Complementary Medicine

2nd Saturday KEYNOTE: Dipnarine Maharaj, MD, South Florida Bone Marrow/Stem Cell Transplant Institute

Colorectal cancer SURIVIVOR/THRIVER Chris Wark, Founder Chris Beat Cancer

Sara Carapezzi, Yoga and Meditation teacher

Dominic D’Agostino, Assistant Professor, Department of Molecular Pharmacology and Physiology at the University of South Florida speaking on Hyberbaric Oxygen with Angela Poff.

Adam J. Messenger, MD, Marsha Valutis, PhD, Daniel Weber, PhD, MSc, Penny Block, PhD, George Love, DOM, Ashwin Mehta, MD, Tony Jimenez, MD, Dickie Walls, AP

Our ever popular Patient Panel,  moderated by Julia Chiappetta

Special Track for Breast Cancer issues on Saturday morning, March 8.  Judy Fitzgerald, Author/Survivor/Thriver, Susan Gonzalez, RN, BSN, Author, Susan McHugh (sexual intimacy and more), moderated by Helayne Waldman, Ed.D, MS

If you plan to stay at the CONFERENCE Hotel, use the link on the registration page on our website.  Special price of $179 per night offers two person Suite (with couch so could have a third).

Participants limited to 200.   You may attend for one day or more.  Thursday $50, Friday or Saturday $100 each.

http://tinyurl.com/mnytkra  All conference details here.

January 9, 2014
by Helayne
1 Comment


Are you ready for a FREE online event that can forever change the way you understand nutrition, health and personal transformation? Please join us for the 1st Online Future of Nutrition Conference with Marc David and The Institute for the Psychology of Eating. Sign up for FREE here: https://ipe.infusionsoft.com/go/fnchome/HelayneWaldman.  Helayne will be joined by over 45 experts who’ll be sharing innovative ideas and compelling insights that can make a big difference in your health, metabolism, weight, energy, digestion, immunity, mood, cognition, and so much more. This unique online event goes live January 27-31. Sign up for FREE here: https://ipe.infusionsoft.com/go/fnchome/HelayneWaldman